Associations between measures of adiposity over 10 years and patella cartilage in population-based asymptomatic women
AJ Gunardi, SL Brennan, Y Wang, Flavia M Cicuttini, JA Pasco, MA Kotowicz, GC Nicholson, Anita Wluka
INTERNATIONAL JOURNAL OF OBESITY | NATURE PUBLISHING GROUP | Published : 2013
OBJECTIVE: Osteoarthritis (OA) most commonly affects the patellofemoral compartment of the knee, and is a major cause of pain and disability. Structural changes that evolve prior to the onset of symptoms can be visualised using magnetic resonance imaging (MRI). There is little known information about the role of adiposity on the early structural changes in the patella cartilage in younger, asymptomatic adult females. METHODS: One hundred and sixty asymptomatic women (20-49 years) participating in the Geelong Osteoporosis Study underwent knee MRI (2006-8). Weight and body mass index (BMI) were measured 10 years prior (1994-7, baseline) and at the time of MRI (current), with change over the pe..View full abstract
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Awarded by National Health and Medical Research Council (NHMRC) of Australia
Awarded by NHMRC
This study was funded by the National Health and Medical Research Council (NHMRC) of Australia (251638, 436665), the Victorian Health Promotion Foundation, LEW Carty Foundation and Arthritis Australia. AJ Gunardi is an Indonesian Honours student of Bachelor of Medical Science from Monash University (23554118). SL Brennan is the recipient of an NHMRC Early Career Fellowship (1012472). AE Wluka is the recipient of an NHMRC Clinical Career Development Award (545876). We thank the participants who made this study possible and the MRI technicians at Barwon Medical Imaging, Barwon Health for their support in imaging the participants.