Perioperative hypothermia (33°C) does not increase the occurrence of cardiovascular events in patients undergoing cerebral aneurysm surgery: Findings from the intraoperative hypothermia for aneurysm surgery trial

HP Nguyen; JG Zaroff; EO Bayman; AW Gelb; MM Todd; BJ Hindman; M Todd; W Clarke; K Chaloner; J Torner; P Davis; M Howard; D Tranel; S Anderson; J Weeks; L Moss; J Winn; W Clarke; M Wichman; R Peters; M Hansen; D Anderson; J Lang; B Yoo; H Adams; G Clifton; W Young; C Loftus; A Schubert; D Warner; R Frankowski; K Kieburtz; D Prough; L Sternau; J Marler; C Moy; B Radziszewska; L Coghlan; R Craen; T Short; R Greif; R Spinka; P Myles; L Litt; M Lawton; M Maktabi; S Samra; B Thompson; A Lam; B Matta; P Kirkpatrick; D Chatfield; C Skilbeck; R Kirollos; F Rasulo; K English; C Duffy; K Pedersen; N Scurrah; R Burnstein; A Prabhu; C Salmond; A Blackwell; J Birrell; S Jackson; N Kassell; T Pajewski; H Fraley; A Morris; T Alden; M Shaffrey; D Bogdonoff; M Durieux; Z Zuo; K Littlewood; E Nemergut; R Bedford; D Stone; P Balestrieri; J Mason; G Henry; P Ting; J Shafer; T Blount; L Kim; A James; E Farace; L Clark; M Irons; T Sasaki; K Webb; E Mee; J Ormrod; J Jane; T Alden; P Heppner; S Olson

Journal article

Perioperative hypothermia (33°C) does not increase the occurrence of cardiovascular events in patients undergoing cerebral aneurysm surgery: Findings from the intraoperative hypothermia for aneurysm surgery trial

HP Nguyen, JG Zaroff, EO Bayman, AW Gelb, MM Todd, BJ Hindman, M Todd, W Clarke, K Chaloner, J Torner, P Davis, M Howard, D Tranel, S Anderson, J Weeks, L Moss, J Winn, W Clarke, M Wichman, R Peters Show all

Anesthesiology | LIPPINCOTT WILLIAMS & WILKINS | Published : 2010

DOI: 10.1097/ALN.0b013e3181dfd4f7

Abstract

Background: Perioperative hypothermia has been reported to increase the occurrence of cardiovascular complications. By increasing the activity of sympathetic nervous system, perioperative hypothermia also has the potential to increase cardiac injury and dysfunction associated with subarachnoid hemorrhage. Methods: The Intraoperative Hypothermia for Aneurysm Surgery Trial randomized patients undergoing cerebral aneurysm surgery to intraoperative hypothermia (n = 499, 33.3° ± 0.8°C) or normothermia (n = 501, 36.7° ± 0.5°C). Cardiovascular events (hypotension, arrhythmias, vasopressor use, myocardial infarction, and others) were prospectively followed until 3-month follow-up and were compared i..

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University of Melbourne Researchers

Bruce R. Thompson Author

John Laidlaw Author

Grants

Awarded by National Institute of Neurological Disorders and Stroke

Funding Acknowledgements

Received from the Department of Anesthesia, Carver College of Medicine, and the Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, Iowa. Submitted for publication November 26, 2009. Accepted for publication March 15, 2010. Supported by grant RO1 NS38554 from the National Institute of Neurological Disease and Stroke, Bethesda, Maryland (to Dr. Todd) and by the Department of Anesthesia, The University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, Iowa. Portions of this work were presented at the 30th International Stroke Conference, New Orleans, Louisiana, February 2-4, 2005, and published in abstract form (Zaroff J, Hindman BJ, Fisher LA, Short T, Greif R, Spinka R, Myles P, Lawton MT, Litt L, Maktabi MA, Samra S, Thompson BG, Lam A, Craen R, Novick T, Gelb AW: Intraoperative hypothermia and the risk of cardiac injury and dysfunction in patients with subarachnoid hemorrhage (abstract). Stroke 2005; 36: 463).