No association between intraoperative hypothermia or supplemental protective drug and neurologic outcomes in patients undergoing temporary clipping during cerebral aneurysm surgery: Findings from the intraoperative hypothermia for aneurysm surgery trial

BJ Hindman; EO Bayman; WK Pfisterer; JC Torner; MM Todd; W Clarke; K Chaloner; P Davis; M Howard; D Tranel; S Anderson; J Winn; M Wichman; R Peters; M Hansen; D Anderson; J Lang; B Yoo; H Adams; G Clifton; A Gelb; C Loftus; A Schubert; D Warner; W Young; R Frankowski; K Kieburtz; D Prough; L Sternau; J Marler; C Moy; B Radziszewska; B Matta; P Kirkpatrick; D Chatfield; C Skilbeck; R Kirollos; F Rasulo; K English; C Duffy; K Pedersen; N Scurrah; R Burnstein; A Prabhu; C Salmond; A Blackwell; J Birrell; S Jackson; N Kassell; T Pajewski; H Fraley; A Morris; T Alden; M Shaffrey; D Bogdonoff; M Durieux; Z Zuo; K Littlewood; E Nemergut; R Bedford; D Stone; P Balestrieri; J Mason; G Henry; P Ting; J Shafer; T Blount; L Kim; A James; E Farace; L Clark; M Irons; T Sasaki; K Webb; T Short; E Mee; J Ormrod; J Jane; T Alden; P Heppner; S Olson; D Ellegala; C Lind; J Sheehan; M Woodfield; A Law; M Harrison; P Davies; D Campbell; N Robertson; R Fry; D Sage; S Laurent; C Bradfield; K Pedersen; K Smith; Y Young; C Chambers; B Hodkinson; J Biddulph

Journal article

No association between intraoperative hypothermia or supplemental protective drug and neurologic outcomes in patients undergoing temporary clipping during cerebral aneurysm surgery: Findings from the intraoperative hypothermia for aneurysm surgery trial

BJ Hindman, EO Bayman, WK Pfisterer, JC Torner, MM Todd, W Clarke, K Chaloner, P Davis, M Howard, D Tranel, S Anderson, J Winn, M Wichman, R Peters, M Hansen, D Anderson, J Lang, B Yoo, H Adams, G Clifton Show all

Anesthesiology | LIPPINCOTT WILLIAMS & WILKINS | Published : 2010

DOI: 10.1097/ALN.0b013e3181c5e28f

Abstract

Background: Although hypothermia and barbiturates improve neurologic outcomes in animal temporary focal ischemia models, the clinical efficacy of these interventions during temporary occlusion of the cerebral vasculature during intracranial aneurysm surgery (temporary clipping) is not established. Methods: A post hoc analysis of patients from the Intraoperative Hypothermia for Aneurysm Surgery Trial who underwent temporary clipping was performed. Univariate and multivariate logistic regression Methods were used to test for associations between hypothermia, supplemental protective drug, and short-(24-h) and long-term (3-month) neurologic outcomes. An odds ratio more than 1 denotes better outc..

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University of Melbourne Researchers

John Laidlaw Author

Grants

Awarded by National Institute of Neurological Disorders and Stroke

Funding Acknowledgements

Received from Department of Anesthesia, Carver College of Medicine and the Department of Epidemiology College of Public Health, University of Iowa, Iowa City, Iowa. Submitted for publication June 7, 2009. Accepted for publication October 6, 2009. Supported by grant No. R01 NTS38554 from the National Institute Of Neurological Disease and Stroke, Bethesda, Maryland (to M.M.T.). Additional funding was provided by the Department of Anesthesia, The University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City Iowa.