Visual contrast sensitivity in major depressive disorder
Johnson Fam, A John Rush, Benjamin Haaland, Sylvaine Barbier, Chi Luu
JOURNAL OF PSYCHOSOMATIC RESEARCH | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2013
OBJECTIVE: Through the eyes of those depressed, the world may appear dull and gray. Visual contrast sensitivity has recently been reported to be lower in depressed patients compared to healthy controls. We aimed to examine the consistency of this finding and to explore the underlying retinal electrophysiology. METHODS: Twenty subjects with major depressive disorder and 20 matched healthy controls were studied. Pattern electroretinogram (PERG) and subjective visual contrast test were used to assess visual contrast sensitivity. Full-field electroretinography (ffERG) was additionally used to assess retinal neurophysiology. Depression was diagnosed based on the Diagnostic and Statistical Manual ..View full abstract
J. Fam has received research support from the National Medical Research Council and Duke-NUS, Singapore. A.J. Rush has received consulting fees from Advanced Neuromodulation Systems, Best Practice Project Management, Otsuka, University of Michigan and Brain Resource; has received consultant/speaker fees from Forest Pharmaceuticals and Singapore College of Family Physicians; has received consultant fees and is a stockholder of Pfizer; has received author royalties from Guilford Publications, Healthcare Technology Systems and the University of Texas Southwestern Medical Center, meeting travel grant from CINP and has received research support from the National Institute of Mental Health, USA. C. Luu has received Operational Infrastructure Support from the Victorian Government, Australia. B. Haaland has received research support from the National Medical Research Council, National University of Singapore and Ministry of Health, Singapore.