Journal article
Clinical Profile of PiB-Positive Corticobasal Syndrome
JR Burrell, M Hornberger, VL Villemagne, CC Rowe, JR Hodges
Plos One | Published : 2013
Abstract
Background: Corticobasal syndrome (CBS) is a multifaceted neurodegenerative disorder characterized by a combination of motor and cognitive deficits. Several different pathological entities, including Alzheimer's pathology, have been described in association with CBS. The present study aimed to establish clinical, neuropsychological, and neuroimaging features that could be useful in the distinction of CBS due to AD pathology from other CBS cases in life based on [11C] Pittsburgh Compound B positron emission tomography (PiB-PET) status. Methods: Patients with CBS were prospectively recruited from a specialized cognitive disorders clinic. All patients underwent detailed clinical and neuropsycho..
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Funding Acknowledgements
This study was funded by the National Health and Medical Research Council of Australia. In addition, JRB gratefully acknowledges funding support from the Motor Neuron Disease Research Institute of Australia, JRH is supported by Australian Research Council Federation Fellowships, and MH is supported by an Australian Research Council grant. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.