Fetuin-A-Containing Calciprotein Particles Reduce Mineral Stress in the Macrophage
Edward R Smith, Eric Hanssen, Lawrence P McMahon, Stephen G Holt
PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2013
The formation of fetuin-A-containing calciprotein particles (CPP) may facilitate the clearance of calcium phosphate nanocrystals from the extracellular fluid. These crystals may otherwise seed extra-osseous mineralization. Fetuin-A is a partially phosphorylated glycoprotein that plays a critical role in stabilizing these particles, inhibiting crystal growth and aggregation. CPP removal is thought to be predominantly mediated by cells of the reticuloendothelial system via type I and type II class A scavenger receptor (SR-AI/II). Naked calcium phosphate crystals are known to stimulate macrophages and other cell types in vitro, but little is known of the effect of CPP on these cells. We report ..View full abstract
This work was kindly supported by funding from Eastern Health, Monash University and an unrestricted investigator-initated research grant from Amgen Australia Pty. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.The authors have the following interests. This study was partly funded by an unrestricted investigator-initated research grant from Amgen Australia Pty. SGH has received research funding and or honoraria from Amgen, Baxter, Gilead & Shire. LPM has received research funding and or honoraria from Amgen, Roche & Shire. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.