Journal article
Effects of NRG1 and DAOA genetic variation on transition to psychosis in individuals at ultra-high risk for psychosis
CA Bousman, AR Yung, C Pantelis, JA Ellis, RA Chavez, B Nelson, A Lin, SJ Wood, GP Amminger, D Velakoulis, PD McGorry, IP Everall, DL Foley
Translational Psychiatry | Published : 2013
DOI: 10.1038/tp.2013.23
Abstract
Prospective studies have suggested genetic variation in the neuregulin 1 (NRG1) and D-amino-acid oxidase activator (DAOA) genes may assist in differentiating high-risk individuals who will or will not transition to psychosis. In a prospective cohort (follow-up=2.4-14.9 years) of 225 individuals at ultra-high risk (UHR) for psychosis, we assessed haplotype-tagging single-nucleotide polymorphisms (htSNPs) spanning NRG1 and DAOA for their association with transition to psychosis, using Cox regression analysis. Two NRG1 htSNPs (rs12155594 and rs4281084) predicted transition to psychosis. Carriers of the rs12155594 T/T or T/C genotype had a 2.34 (95% confidence interval (CI)=1.37-4.00) times grea..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
We thank HP Yuen for his assistance with data management. We also thank the young people who participated. DNA was provided by Genetic Repositories Australia, an Enabling Facility supported by NHMRC Grant number 401184, and samples were collected by Orygen Youth Health Research Centre, Centre for Youth Mental Health. This work was supported by Colonial Foundation (Australia) (PDM; ARY; DLF); National Health and Medical Research Council of Australia Project Grants and Program Grant (ARY, CP, PDM); John McKenzie Post-Doctoral Fellowship (CAB); NHMRC Senior Research Fellowship (ARY); NHMRC Senior Principal Research Fellowship (CP); Ronald Phillip Griffith Fellowship and NHMRC Career Development Fellowship (BN).