Ketosis and appetite-mediating nutrients and hormones after weight loss
P Sumithran, LA Prendergast, E Delbridge, K Purcell, A Shulkes, A Kriketos, J Proietto
EUROPEAN JOURNAL OF CLINICAL NUTRITION | NATURE PUBLISHING GROUP | Published : 2013
BACKGROUND/OBJECTIVES: Diet-induced weight loss is accompanied by compensatory changes, which increase appetite and encourage weight regain. There is some evidence that ketogenic diets suppress appetite. The objective is to examine the effect of ketosis on a number of circulating factors involved in appetite regulation, following diet-induced weight loss. SUBJECTS/METHODS: Of 50 non-diabetic overweight or obese subjects who began the study, 39 completed an 8-week ketogenic very-low-energy diet (VLED), followed by 2 weeks of reintroduction of foods. Following weight loss, circulating concentrations of glucose, insulin, non-esterified fatty acids (NEFA), β-hydroxybutyrate (BHB), leptin, gastro..View full abstract
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Awarded by NHMRC
This work was supported by NHMRC project grant (508920), Endocrine Society of Australia scholarship (PS), Royal Australasian College of Physicians Shields Research Entry scholarship (PS), and Sir Edward Dunlop Medical Research Foundation (JP). We thank Celestine Bouniu, John Cardinal, Sherrell Cardinal, Christian Rantzau, Rebecca Sgambellone, Sherley Visinoni and Mildred Vim for technical assistance.