Journal article

Therapeutic strategies that target epigenetic, paracrine and signalling control of skeletal muscle regeneration

G Smythe, J White

Current Regenerative Medicine | Published : 2013

Abstract

Skeletal muscle is highly efficient at self-repair following injury via a complex interplay of muscle and non-muscle cellular components, soluble growth factors, and the extracellular matrix. Under certain circumstances, such as after extensive acute tissue injury, prolonged periods of muscle disuse, and in some diseases, the regenerative capacity of muscle can be overwhelmed or impaired. Predictive muscle break down can also occur (e.g., in age-related loss of muscle mass and function, and post-operatively when procedures involve direct muscle damage, denervation or loss of blood supply), and strategies that facilitate muscle regeneration and reduce recovery time or the effects of ageing wo..

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University of Melbourne Researchers