Journal article

Cholinergic connectivity: it's implications for psychiatric disorders

Elizabeth Scarr, Andrew S Gibbons, Jaclyn Neo, Madhara Udawela, Brian Dean

FRONTIERS IN CELLULAR NEUROSCIENCE | FRONTIERS MEDIA SA | Published : 2013

Abstract

Acetylcholine has been implicated in both the pathophysiology and treatment of a number of psychiatric disorders, with most of the data related to its role and therapeutic potential focusing on schizophrenia. However, there is little thought given to the consequences of the documented changes in the cholinergic system and how they may affect the functioning of the brain. This review looks at the cholinergic system and its interactions with the intrinsic neurotransmitters glutamate and gamma-amino butyric acid as well as those with the projection neurotransmitters most implicated in the pathophysiologies of psychiatric disorders; dopamine and serotonin. In addition, with the recent focus on t..

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Grants

Awarded by National Medical and Health Research Council


Awarded by Australian Research Council


Funding Acknowledgements

This work was supported by the National Medical and Health Research Council (Senior Research Fellowship #APP1002240 to Brian Dean), the Australian Research Council (Future Fellowship FT100100689 to Elizabeth Scarr) as well as Operational Infrastructure Support (OIS) from the Victorian State Government.