Measuring thyroid peroxidase antibodies on the day nulliparous women present for management of miscarriage: a descriptive cohort study
Mathis Grossmann, Rudolf Hoermann, Claire Francis, Emma J Hamilton, Aye Tint, Tu'uhevaha Kaitu'u-Lino, Kent Kuswanto, Martha Lappas, Ken Sikaris, Jeffery D Zajac, Michael Permezel, Stephen Tong
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY | BIOMED CENTRAL LTD | Published : 2013
BACKGROUND: There has been recent evidence suggesting the presence of anti-thyroid peroxidase antibodies (TPOAb) increases the risk of miscarriage, and levothyroxine can rescue miscarriages associated with TPOAb. We propose the most clinically pragmatic cohort to screen for TPOAb are women presenting for management of a missed miscarriage and have never birthed a liveborn. We measured serum TPOAb among nulliparous women presenting for management of miscarriage, and compared levels with women who have had 2 or more livebirths (and never miscarried). Given its potential role in immunomodulation, we also measured Vitamin D levels. METHODS: We performed a prospective descriptive cohort study at ..View full abstract
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Awarded by National Health and Medical Research Council of Australia
We would like to thank Dr. Zhong Lu, Melbourne Pathology, Collingwood, Victoria for her help in performing the biochemical assays. Funded by The National Health and Medical Research Council of Australia (# 400417, # 1006407, # 1050765) and Royal Australasian College of Physicians.