Journal article

Antibiotic susceptibility of Aggregatibacter actinomycetemcomitans JP2 in a biofilm

Orit Oettinger-Barak, Stuart G Dashper, Deanne V Catmull, Geoffrey G Adams, Michael N Sela, Eli E Machtei, Eric C Reynolds

JOURNAL OF ORAL MICROBIOLOGY | CO-ACTION PUBLISHING | Published : 2013

Abstract

BACKGROUND: Localized aggressive periodontitis (LAgP) is an inflammatory disease associated with specific bacteria, particularly Aggregatibacter actinomycetemcomitans, which can result in early tooth loss. The bacteria grow as a biofilm known as subgingival plaque. Treatment includes mechanical debridement of the biofilm, often associated with empirical antibiotic treatment. OBJECTIVE: The aims of this study were to test in vitro the sensitivity of A. actinomycetemcomitans JP2 during planktonic and biofilm growth to doxycycline and to the combination of metronidazole and amoxicillin, which are two antibiotic protocols commonly used in clinical practice. DESIGN: Two in vitro biofilm models we..

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Grants

Funding Acknowledgements

The project was partially supported by the Australia-Israel Scientific Exchange Foundation Fellowship.