Antibiotic susceptibility of Aggregatibacter actinomycetemcomitans JP2 in a biofilm
Orit Oettinger-Barak, Stuart G Dashper, Deanne V Catmull, Geoffrey G Adams, Michael N Sela, Eli E Machtei, Eric C Reynolds
JOURNAL OF ORAL MICROBIOLOGY | CO-ACTION PUBLISHING | Published : 2013
BACKGROUND: Localized aggressive periodontitis (LAgP) is an inflammatory disease associated with specific bacteria, particularly Aggregatibacter actinomycetemcomitans, which can result in early tooth loss. The bacteria grow as a biofilm known as subgingival plaque. Treatment includes mechanical debridement of the biofilm, often associated with empirical antibiotic treatment. OBJECTIVE: The aims of this study were to test in vitro the sensitivity of A. actinomycetemcomitans JP2 during planktonic and biofilm growth to doxycycline and to the combination of metronidazole and amoxicillin, which are two antibiotic protocols commonly used in clinical practice. DESIGN: Two in vitro biofilm models we..View full abstract
The project was partially supported by the Australia-Israel Scientific Exchange Foundation Fellowship.