Failure of collateral blood flow is associated with infarct growth in ischemic stroke
Bruce CV Campbell, Soren Christensen, Brian M Tress, Leonid Churilov, Patricia M Desmond, Mark W Parsons, P Alan Barber, Christopher R Levi, Christopher Bladin, Geoffrey A Donnan, Stephen M Davis
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | NATURE PUBLISHING GROUP | Published : 2013
Changes in collateral blood flow, which sustains brain viability distal to arterial occlusion, may impact infarct evolution but have not previously been demonstrated in humans. We correlated leptomeningeal collateral flow, assessed using novel perfusion magnetic resonance imaging (MRI) processing at baseline and 3 to 5 days, with simultaneous assessment of perfusion parameters. Perfusion raw data were averaged across three consecutive slices to increase leptomeningeal collateral vessel continuity after subtraction of baseline signal analogous to digital subtraction angiography. Changes in collateral quality, Tmax hypoperfusion severity, and infarct growth were assessed between baseline and d..View full abstract
Awarded by National Health and Medical Research Council (NHMRC) of Australia
The EPITHET study was supported by the National Health and Medical Research Council (NHMRC) of Australia, National Stroke Foundation and National Heart Foundation of Australia. Infrastructure support was received for these studies through the Victorian Government Operational Infrastructure Program to the Florey Institute of Neuroscience and Mental Health. Dr Campbell has received research support from the National Health and Medical Research Council (NHMRC) of Australia (postgraduate scholarship 567156, early career fellowship 1035688), the Heart Foundation of Australia, National Stroke Foundation, a Cardiovascular Lipid (CVL) Australia grant and the Neuroscience Foundation of the Royal Melbourne Hospital.