Journal article

Incidence of total knee and hip replacement for osteoarthritis in relation to the metabolic syndrome and its components: A prospective cohort study

Sultana Monira Hussain, Yuanyuan Wang, Flavia M Cicuttini, Julie A Simpson, Graham G Giles, Stephen Graves, Anita Wluka

SEMINARS IN ARTHRITIS AND RHEUMATISM | W B SAUNDERS CO-ELSEVIER INC | Published : 2014

Abstract

OBJECTIVE: To examine whether components of metabolic syndrome (MetS), either singly or additively, were associated with the incidence of severe knee and hip OA, and whether these associations were independent of obesity assessed by body mass index (BMI). METHODS: Twenty thousand, four hundred and thirty participants who had blood lipids, anthropometric and blood pressure measurements during 2003-2007 were selected from the Melbourne Collaborative Cohort Study. MetS was defined as central obesity assessed by waist circumference and any two of raised triglyceride level, reduced HDL cholesterol level, hypertension or impaired fasting glycaemia. The incidence of total knee and hip replacement w..

View full abstract

Grants

Awarded by National Health and Medical Research Council (NHMRC)


Awarded by Capacity Building Grant


Awarded by Enabling Grant


Awarded by NHMRC Career Development Fellowship


Funding Acknowledgements

The recruitment of the Melbourne Collaborative Cohort Study was funded by Vic Health and Cancer Council Victoria. This study was funded by a programme Grant from the National Health and Medical Research Council (NHMRC; 209057), Capacity Building Grant (251533), and Enabling Grant (396414), and was further supported by infrastructure provided by the Cancer Council Victoria. Dr Wluka is the recipient of NHMRC Career Development Fellowship (Clinical, level 1, #545876).