Journal article
Biomarkers of inflammation and coagulation are associated with mortality and hepatitis flares in persons coinfected with HIV and hepatitis viruses
BB Andrade, KH Hullsiek, DR Boulware, A Rupert, MA French, K Ruxrungtham, ML Montes, H Price, P Barreiro, J Audsley, A Sher, SR Lewin, I Sereti
Journal of Infectious Diseases | Published : 2013
Abstract
Background. Hepatitis C virus (HCV) and/or hepatitis B virus (HBV) coinfection with human immunodeficiency virus (HIV) has a greater risk of mortality than either HCV or HBV infection alone and is frequently associated with hepatitis flares after antiretroviral therapy (ART) initiation.Methods. We performed a retrospective cohort study of 287 HIV-positive persons coinfected with HBV and/or HCV (70 had HBV coinfection only, 207 had HCV coninfection only, and 10 had HBV and HCV coinfections) who had pre-ART plasma samples evaluated for biomarkers associated with death (within 4 years) and/or hepatitis flare (within 4 months) after ART initiation. A predictive biomarker risk score was calculate..
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Awarded by National Institutes of Health
Funding Acknowledgements
This work was supported in part by the National Institute of Allergy and Infectious Diseases (NIAID; grants 3 U01 AI068641-05S1, U01AI042170, and U01AI046362) and the NIAID Intramural Research Program, National Institutes of Health; the National Research University Project of CHE and the Ratchadaphiseksomphot Endowment Fund, Thailand (grant HR1161A to K. R.); the National Science and Technology Development Agency, BIOTEC (grant to K. R.); and the Thai Research Fund, Thailand (to K. R.).