Journal article
CELF expression in epilepsy linked to sodium channels
M Oliva, S Petrou
Future Neurology | FUTURE MEDICINE LTD | Published : 2013
DOI: 10.2217/fnl.13.13
Abstract
Evaluation of: Sun W, Wagnon JL, Mahaffey CL et al. Aberrant sodium channel activity in the complex seizure disorder of Celf4 mutant mice. J. Physiol. 591(1), 241255 (2013). The choreographed expression of ion channels is critical for normal brain activity, as evidenced by the range of epilepsy syndromes associated with ion channel genetic variation. As large-scale sequencing efforts, such as Epi4K and EuroEPINOMICS, systematically deconstruct epilepsy genomes, it is likely that further progress will be made in our understanding of how ion channel dysfunction results in epilepsy. By contrast, our knowledge of non-ion channel genes in epilepsy is far less advanced, a problem frequently compou..
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Funding Acknowledgements
The authors would like to acknowledge the National Health and Medical Research Council and the Australian Research Council for grants and fellowships. The Florey Institute of Neuroscience and Mental Health is supported by the Victorian Government through the Operational Infrastructure Scheme. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.