Journal article

The adjuvant management of endometrial cancer: A review of the role of systemic therapy

L Mileshkin, S Jamil

European journal of Clinical and Medical Oncology | Published : 2011


Endometrial cancer usually presents with early-stage disease and may be cured by surgery alone. However, women with more advanced stages or high-risk pathological features have a high risk of relapse if treated with surgery alone. Adjuvant radiotherapy reduces the local relapse risk but does not impact on overall survival (OS), as the major risk is developing distant metastases. There is of great interest in the ability of adjuvant chemotherapy to lower this risk and we review the available prospective data about adjuvant systemic therapy. Several prospective randomized trials involving adjuvant chemotherapy have been performed, with only one trial (GOG122) reporting an OS advantage for adju..

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University of Melbourne Researchers