Journal article
Effectiveness of artemether/lumefantrine for the treatment of uncomplicated plasmodium vivax and P. falciparum malaria in young children in papua New Guinea
N Senn, P Rarau, D Manong, M Salib, P Siba, JC Reeder, SJ Rogerson, B Genton, I Mueller
Clinical Infectious Diseases | OXFORD UNIV PRESS INC | Published : 2013
DOI: 10.1093/cid/cit068
Abstract
Background. Artemisinin combination therapy is recommended as treatment for uncomplicated Plasmodium falciparum (Pf) malaria, whereas chloroquine is still widely used for non-Pf infections. A common treatment for both vivax and falciparum malaria would be welcome.Methods. A longitudinal prospective effectiveness study of 1682 children aged 3-27 months in outpatient clinics in Papua New Guinea. The main outcome was clinical treatment failure rate following treatment with artemether/lumefantrine (AL).Results. Among 5670 febrile episodes, 1682 (28%) had positive rapid diagnostic test (RDT) results and were treated with AL. A total of 1261 (22%) had an infection confirmed by blood slide examinat..
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Funding Acknowledgements
The data used in this work were collected through an IPTi randomized controlled trial funded by a grant from the Bill & Melinda Gates Foundation to the PNG IMR.