Journal article
Migrating partial seizures of infancy: Expansion of the electroclinical, radiological and pathological disease spectrum
A McTague, R Appleton, S Avula, JH Cross, MD King, TS Jacques, S Bhate, A Cronin, A Curran, A Desurkar, MA Farrell, E Hughes, R Jefferson, K Lascelles, J Livingston, E Meyer, A McLellan, A Poduri, IE Scheffer, S Spinty Show all
Brain | Published : 2013
DOI: 10.1093/brain/awt073
Abstract
Migrating partial seizures of infancy, also known as epilepsy of infancy with migrating focal seizures, is a rare early infantile epileptic encephalopathy with poor prognosis, presenting with focal seizures in the first year of life. A national surveillance study was undertaken in conjunction with the British Paediatric Neurology Surveillance Unit to further define the clinical, pathological and molecular genetic features of this disorder. Fourteen children with migrating partial seizures of infancy were reported during the 2 year study period (estimated prevalence 0.11 per 100 000 children). The study has revealed that migrating partial seizures of infancy is associated with an expanded spe..
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Funding Acknowledgements
A.M. and R. K. received funding from the Neurology Charitable Fund (Alder Hey Children's Hospital) for the BPNSU study. M. A. K. is a Wellcome Trust appointed Intermediate Clinical Fellow. Genetic investigations undertaken on a research basis in this study were funded by the MPSI support group, Action Medical Research, the UK Childrens Neurological Research Campaign (UKCNRC), Roald Dahl's Marvellous Children's Charity and Great Ormond Street Hospital Children's Charities (GOSHCC).