Predictors for developing intestinal failure in patients with Crohn's disease
Richard B Gearry, Michael A Kamm, Ailsa L Hart, Paul Bassett, Simon M Gabe, Jeremy M Nightingale
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | WILEY | Published : 2013
BACKGROUND AND AIM: Intestinal failure (IF) is a rare but devastating complication of Crohn's disease (CD). The clinical and surgical factors that predispose to IF are poorly understood. The aim of this study was to define clinical factors that predispose to IF. METHODS: A retrospective case-control study was performed using consecutive CD patients with IF who were identified from a prospective database. Local population-based controls were selected with which to compare demographic, phenotypic, and clinical outcomes. RESULTS: Eighty-two CD patients requiring long-term intravenous fluids or nutrition were studied. Diagnosis at age 16 years or less (P = 0.01) and a family history of inflammat..View full abstract
Dr Gearry received funding from the following agencies to support this research:Don Beaven Travelling Fellowship (Canterbury Medical Research Foundation), Maurice and Phyllis Paykel Trust, The Olympus-New Zealand Society of Gastroenterology Travelling Fellowship, The Bowel and Liver Trust, Christchurch, The Canterbury Gastroenterology Research Trust.