Control of extravillous trophoblast function by the eotaxins CCL11, CCL24 and CCL26
Simon E Chau, Padma Murthi, May H Wong, Guy StJ Whitley, Shaun P Brennecke, Rosemary J Keogh
HUMAN REPRODUCTION | OXFORD UNIV PRESS | Published : 2013
STUDY QUESTION: What are the effects of the eotaxin group of chemokines (CCL11, CCL24 and CCL26) on extravillous trophoblast (EVT) functions important during uterine decidual vessel remodelling? SUMMARY ANSWER: CCL11, CCL24 and CCL26 can regulate EVT migration, invasion and adhesion, highlighting a potential regulatory role for these chemokines during uterine decidual spiral arteriole remodelling in the first trimester of human pregnancy. WHAT IS KNOWN ALREADY: A successful human pregnancy depends on adequate remodelling of the uterine decidual spiral arterioles, a process carried out by EVT which invade from the placenta. The invasion by EVT into the maternal uterine decidual vessels is reg..View full abstract
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Awarded by Heart Foundation, Australia
This work was supported by a grant from the Heart Foundation, Australia (G10M 5185).