Adult serum cytokine concentrations and the persistence of asthma

RK Kandane-Rathnayake; MLK Tang; JA Simpson; JA Burgess; D Mészáros; I Feather; MC Southey; CJ Schroen; J Hopper; SC Morrison; GG Giles; EH Walters; SC Dharmage; MC Matheson

Journal article

Adult serum cytokine concentrations and the persistence of asthma

RK Kandane-Rathnayake, MLK Tang, JA Simpson, JA Burgess, D Mészáros, I Feather, MC Southey, CJ Schroen, J Hopper, SC Morrison, GG Giles, EH Walters, SC Dharmage, MC Matheson

International Archives of Allergy and Immunology | KARGER | Published : 2013

DOI: 10.1159/000346910

Abstract

Background: Cytokines play a pivotal role in regulating the development and persistence of the inflammatory process in asthma. Our aim was to investigate whether asthma persistence or remission is associated with a specific cytokine profile. Methods: The Tasmanian Longitudinal Health Study followed participants from 7 to 44 years of age. Serum concentrations of interleukin (IL)-4, IL-5, IL-6, IL-8, IL-10 and tumor necrosis factor-alpha (TNF-α) were measured at age 44 years. Participants were categorized into five phenotypes (early-onset noncurrent asthma, early-onset current asthma, late-onset noncurrent asthma and late-onset current asthma). Those who had never had asthma formed the referen..

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University of Melbourne Researchers

Mimi Tang Author

Julie Simpson Author

John Burgess Author

Melissa Southey Author

Grants

Funding Acknowledgements

We acknowledge the continued support and participation of the Tasmanian Asthma Study and all previous investigators of the TAHS. We acknowledge several current TAHS investigators who are not coauthors of this manuscript: Prof. Michael J. Abramson, Associate Prof. David P. Johns, Dr. James Markos, Associate Prof. Paul Thomas, Dr. Bruce Thomson, Dr. Richard Wood-Baker and Associate Prof. Mark A. Jenkins. Thanks to all the respiratory scientists who collected data in the lung function laboratories of Tasmania, Victoria, Queensland and New South Wales. This study was funded by the National Health and Medical Research Council of Australia, LEW Carty charitable funds, Clifford Craig Medical Research Trust of Tasmania and Victorian & Tasmanian Asthma Foundations. R.K.K.-R., M.C.M., S.C.D. and J.H. were supported by the National Health and Medical Research Council. We would like to thank Ms Cathryn Wharton, the project coordinator of the TAHS probands laboratory study, for all her hard work.