Journal article
Can structural or functional changes following traumatic brain injury in the rat predict epileptic outcome?
SR Shultz, L Cardamone, YR Liu, R Edward Hogan, L MacCotta, DK Wright, P Zheng, A Koe, MC Gregoire, JP Williams, RJ Hicks, NC Jones, DE Myers, TJ O'Brien, V Bouilleret
Epilepsia | WILEY | Published : 2013
DOI: 10.1111/epi.12223
Abstract
Purpose Posttraumatic epilepsy (PTE) occurs in a proportion of traumatic brain injury (TBI) cases, significantly compounding the disability, and risk of injury and death for sufferers. To date, predictive biomarkers for PTE have not been identified. This study used the lateral fluid percussion injury (LFPI) rat model of TBI to investigate whether structural, functional, and behavioral changes post-TBI relate to the later development of PTE. Methods Adult male Wistar rats underwent LFPI or sham injury. Serial magnetic resonance (MR) and positron emission tomography (PET) imaging, and behavioral analyses were performed over 6 months postinjury. Rats were then implanted with recording electrode..
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Awarded by National Center for Advancing Translational Sciences
Funding Acknowledgements
We wish to acknowledge the staff of the Howard Florey Institute Small Animal MRI Facility, and the Peter MacCallum Cancer Centre. Funding for this project was provided by the Victorian Government Transport Accident Commission (DP0023). N.J. and T.O. acknowledge the financial support of the NHMRC of Australia.