Journal article

Response of Leptospira interrogans to physiologic osmolarity: Relevance in signaling the environment-to-host transition

James Matsunaga, Miranda Lo, Dieter M Bulach, Richard L Zuerner, Ben Adler, David A Haake

INFECTION AND IMMUNITY | AMER SOC MICROBIOLOGY | Published : 2007

Abstract

Transmission of pathogenic Leptospira between mammalian hosts usually involves dissemination via soil or water contaminated by the urine of carrier animals. The ability of Leptospira to adapt to the diverse conditions found inside and outside the host is reflected in its relatively large genome size and high percentage of signal transduction genes. An exception is Leptospira borgpetersenii serovar Hardjo, which is transmitted by direct contact and appears to have lost genes necessary for survival outside the mammalian host. Invasion of host tissues by Leptospira interrogans involves a transition from a low osmolar environment outside the host to a higher physiologic osmolar environment withi..

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University of Melbourne Researchers