Journal article
Development of chondrosarcoma animal models for assessment of adjuvant therapy
JCM Clark, CR Dass, PFM Choong
ANZ Journal of Surgery | Published : 2009
Abstract
Chondrosarcoma is a primary cancer of bone causing significant morbidity due to local recurrence and limited treatment options. Relatively few chondrosarcoma animal models have been developed, and the only orthotopic model is technically demanding and has limited clinical relevance. The aim of this review is to assess the features of current animal chondrosarcoma models for the purpose of developing new models in which to test adjuvant chondrosarcoma therapy. The available literature on this topic was identified using the PubMed database, and then analysed for relevance to the human chondrosarcoma disease and feasibility in testing new therapeutic agents. Animal-derived chondrosarcoma models..
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Funding Acknowledgements
The Department of Anatomical Pathology, St Vincent's Hospital assisted with histological sections. Micro CT imaging of an orthotopic mouse osteosarcoma model (Fig. 5) (developed by The Department of Orthopaedics, St Vincent's Hospital, University of Melbourne) was kindly performed by A. Evdokiou and A. Labrinidis in The Department of Orthopaedics, Royal Adelaide Hospital, Adelaide University. J. C. M. C has been funded by the generous support of the Royal Australasian College of Surgeons through the Foundation for Surgery Reg Worcester Research Fellowship, The St Vincent's Hospital Research Endowment Fund and a National Health and Medical Research Council Scholarship.