Journal article
SOCS regulation of the JAK/STAT signalling pathway
BA Croker, H Kiu, SE Nicholson
Seminars in Cell and Developmental Biology | Published : 2008
Abstract
The suppressor of cytokine signalling (SOCS) proteins were, as their name suggests, first described as inhibitors of cytokine signalling. While their actions clearly now extend to other intracellular pathways, they remain key negative regulators of cytokine and growth factor signalling. In this review we focus on the mechanics of SOCS action and the complexities of the mouse models that have underpinned our current understanding of SOCS biology. © 2008 Elsevier Ltd. All rights reserved.
Grants
Awarded by National Cancer Institute
Funding Acknowledgements
This work was supported in part by the National Health and Medical Research Council (NHMRC), Australia (Program Grant #257500 and Project Grant #461232) and in part by the National Institutes of Health (RO1 CA22556-26). S. E. N. was supported by an NHMRC Biomedical Career Development Award, B. A. C by an NHMRC CJ Martin Fellowship and H. K. by an NHMRC Biomedical Postgraduate Research Scholarship. We are grateful to W. Alexander for reviewing this manuscript and to A. Roberts for helpful comments.