Journal article

Neural Differentiation of Induced Pluripotent Stem Cells

Mark Denham, Mirella Dottori, G Manfredi (ed.), H Kawamata (ed.)

Methods in Molecular Biology | HUMANA PRESS INC | Published : 2011

Abstract

The great potential of induced pluripotent cells (iPS) cells is that it allows the possibility of deriving pluripotent stem cells from any human patient. Generation of patient-derived stem cells serves as a great source for developing cell replacement therapies and also for creating human cellular model systems of specific diseases or disorders. This is only of benefit if there are well-established differentiation assay systems to generate the cell types of interest. This chapter describes robust and well-characterized protocols for differentiating iPS cells to neural progenitors, neurons, glia and neural crest cells. These established assays can be applied to iPS cell lines derived from pat..

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University of Melbourne Researchers