Increased Helicobacter felis colonization in male 129/Sv mice fails to suppress gastritis (vol 2, pg 358, 2011)
Garrett Z Ng, Alison L Every, Michael A McGuckin, Philip Sutton
Gut Microbes | TAYLOR & FRANCIS INC | Published : 2011
Development of the pathologies associated with Helicobacter pylori infection, most seriously gastric adenocarcinoma, are a consequence of chronic inflammation, which both host and pathogen go to some lengths to minimize. Recently, we presented evidence that H. pylori can suppress the development of inflammation in its immediate microenvironment in the gastric mucosa of 129/Sv mice. We have now extended this study by showing that H. felis, a gastric colonizing Helicobacter closely related to H. pylori, does not possess the same ability to suppress Helicobacter-induced gastritis in mice. Differences between these bacterial species may provide clues as to the mechanism behind the inflammation-r..View full abstract
Awarded by National Health and Medical Research Council of Australia
This work was funded by project grant #543704 from the National Health and Medical Research Council of Australia.