Journal article
Differential role of MyD88 and Mal/TIRAP in TLR2-mediated gastric tumourigenesis
CL Kennedy, M Najdovska, H Tye, L McLeod, L Yu, A Jarnicki, PS Bhathal, T Putoczki, M Ernst, BJ Jenkins
Oncogene | Published : 2014
DOI: 10.1038/onc.2013.205
Abstract
Signalling by the toll-like receptor (TLR) family of pathogen recognition receptors has emerged as a key molecular component in the pathogenesis of an increasing number of inflammatory-related cancers, among which gastric cancer rates as the second most lethal cancer world-wide. The myeloid differentiation factor 88 (MyD88) adapter molecule has a critical role in mediating innate immune signalling by members of the TLR and interleukin (IL)-1 families, and has been associated with either pro- or antitumourigenic responses in various cancer models. However, little is known about the in vivo role of MyD88 adapter-like (Mal)/TIR-domain containing adapter protein (TIRAP), which is restricted to f..
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Funding Acknowledgements
This study was supported by research grants from the Association for International Cancer Research (UK), the Cancer Council of Victoria (Australia) and the National Health and Medical Research Council (Australia), as well as the Operational Infrastructure Support Program by the Victorian Government of Australia. BJ Jenkins is supported by a Senior Medical Research Fellowship awarded by the Sylvia and Charles Viertel Foundation.