Journal article

The C-terminal flanking peptide of progastrin induces gastric cell apoptosis and stimulates colonic cell division in vivo

Kathryn M Marshall, Oneel Patel, Gianni Bramante, Marie Laval, Mildred Yim, Graham S Baldwin, Arthur Shulkes



Progastrin (PG) is processed into a number of smaller peptides including amidated gastrin (Gamide), non-amidated glycine-extended gastrin (Ggly) and the C-terminal flanking peptide (CTFP). Several groups have reported that PG, Gamide and Ggly are biologically active in vitro and in vivo, and are involved in the development of gastrointestinal cancers. CTFP is bioactive in vitro but little is known of its effects in vivo. This study investigated the bioactivity of CTFP in vivo in normal tissues using gastrin deficient (GASKO) mice and in two mouse models of cancer (SCID mice bearing xenograft tumors expressing normal or knocked-down levels of gastrin and a mouse model of hepatic metastasis). ..

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Awarded by National Health and Medical Research Council of Australia

Funding Acknowledgements

This work was supported by grants 1006245 (AS, KMM, GSB) and 1020983 (GSB) from the National Health and Medical Research Council of Australia.