Journal article
Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study: Associations of maternal A1C and glucose with pregnancy outcomes
LP Lowe, DR Coustan, BE Metzger, DR Hadden, AR Dyer, M Hod, J Lowe, JJN Oats, DR Mccance, B Persson, TRJ Lappin, ER Trimble
Diabetes Care | AMER DIABETES ASSOC | Published : 2012
DOI: 10.2337/dc11-1687
Abstract
OBJECTIVE - To compare associations of maternal glucose and A1C with adverse outcomes in the multinational Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study and determine, based on those comparisons, if A1C measurement can provide an alternative to an oral glucose tolerance test (OGTT) in pregnant women. RESEARCH DESIGN AND METHODS - Eligible pregnant women underwent a 75-g OGTT at 24-32weeks' gestation. A sample for A1Cwas also collected.Neonatal anthropometrics and cord serum C-peptide were measured. Associations with outcomes were assessed using multiple logistic regression with adjustment for potential confounders. RESULTS - Among 23,316 HAPO Study participants with glucose levels..
View full abstractGrants
Awarded by National Institute of Child Health and Human Development
Funding Acknowledgements
This study was funded by grants R01-HD-34242 and R01-HD-34243 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development and the National Institute of Diabetes and Digestive and Kidney Diseases; by the National Center for Research Resources (M01-RR-00048 and M01-RR-00080); and by the American Diabetes Association. Support has also been provided to local field centers by Diabetes UK (RD04/0002756), Southern California Permanente Medical Group, KK Women's and Children's Hospital, Mater Mother's Hospital, Novo Nordisk, and the Howard and Carol Bernick Family Foundation. No other potential conflicts of interest relevant to this article were reported.