Variants in MTNR1B influence fasting glucose levels

I Prokopenko; C Langenberg; JC Florez; R Saxena; N Soranzo; G Thorleifsson; RJF Loos; AK Manning; AU Jackson; Y Aulchenko; SC Potter; MR Erdos; S Sanna; JJ Hottenga; E Wheeler; M Kaakinen; V Lyssenko; WM Chen; K Ahmadi; JS Beckmann; RN Bergman; M Bochud; LL Bonnycastle; TA Buchanan; A Cao; A Cervino; L Coin; FS Collins; L Crisponi; EJC De Geus; A Dehghan; P Deloukas; ASF Doney; P Elliott; N Freimer; V Gateva; C Herder; A Hofman; TE Hughes; S Hunt; T Illig; M Inouye; B Isomaa; T Johnson; A Kong; M Krestyaninova; J Kuusisto; M Laakso; N Lim; U Lindblad; CM Lindgren; OT McCann; KL Mohlke; AD Morris; S Naitza; M Orrù; CNA Palmer; A Pouta; J Randall; W Rathmann; J Saramies; P Scheet; LJ Scott; A Scuteri; S Sharp; E Sijbrands; JH Smit; K Song; V Steinthorsdottir; HM Stringham; T Tuomi; J Tuomilehto; AG Uitterlinden; BF Voight; D Waterworth; HE Wichmann; G Willemsen; JCM Witteman; X Yuan; JH Zhao; E Zeggini; D Schlessinger; M Sandhu; DI Boomsma; M Uda; TD Spector; BWJH Penninx; D Altshuler; P Vollenweider; MR Jarvelin; E Lakatta; G Waeber; CS Fox; L Peltonen; LC Groop; V Mooser; LA Cupples; U Thorsteinsdottir; M Boehnke; I Barroso

Journal article

Variants in MTNR1B influence fasting glucose levels

I Prokopenko, C Langenberg, JC Florez, R Saxena, N Soranzo, G Thorleifsson, RJF Loos, AK Manning, AU Jackson, Y Aulchenko, SC Potter, MR Erdos, S Sanna, JJ Hottenga, E Wheeler, M Kaakinen, V Lyssenko, WM Chen, K Ahmadi, JS Beckmann Show all

Nature Genetics | NATURE PUBLISHING GROUP | Published : 2009

DOI: 10.1038/ng.290

Abstract

To identify previously unknown genetic loci associated with fasting glucose concentrations, we examined the leading association signals in ten genome-wide association scans involving a total of 36,610 individuals of European descent. Variants in the gene encoding melatonin receptor 1B (MTNR1B) were consistently associated with fasting glucose across all ten studies. The strongest signal was observed at rs10830963, where each G allele (frequency 0.30 in HapMap CEU) was associated with an increase of 0.07 (95% CI = 0.06-0.08) mmol/l in fasting glucose levels (P = 3.2 × 10-50) and reduced beta-cell function as measured by homeostasis model assessment (HOMA-B, P = 1.1 × 10 -15). The same allele ..

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