A genome-wide association study suggests that a locus within the ataxin 2 binding protein 1 gene is associated with hand osteoarthritis: the Treat-OA consortium
G Zhai, JBJ van Meurs, G Livshits, I Meulenbelt, AM Valdes, N Soranzo, D Hart, F Zhang, BS Kato, JB Richards, FMK Williams, M Inouye, M Kloppenburg, P Deloukas, E Slagboom, A Uitterlinden, TD Spector
Journal of Medical Genetics | B M J PUBLISHING GROUP | Published : 2009
To identify the susceptibility gene in hand osteoarthritis (OA) the authors used a two-stage approach genome-wide association study using two discovery samples (the TwinsUK cohort and the Rotterdam discovery subset; a total of 1804 subjects) and four replication samples (the Chingford Study, the Chuvasha Skeletal Aging Study, the Rotterdam replication subset and the Genetics, Arthrosis, and Progression (GARP) Study; a total of 3266 people). Five single-nucleotide polymorphisms (SNPs) had a likelihood of association with hand OA in the discovery stage and one of them (rs716508), was successfully confirmed in the replication stage (meta-analysis p = 1.81x10(-5)). The C allele conferred a reduc..View full abstract
Awarded by Versus Arthritis
European Community Framework 7 large collaborative project grant Treat-OA, The Wellcome Trust; Arthritis Research Campaign, The study also receives support from the National Institute for Health Research (NIHR) comprehensive Biomedical Research Centre award to Guy's & St Thomas' NHS Foundation Trust in partnership with King's College London. TDS is an NIHR senior Investigator. The project also received support from a Biotechnology and biological Sciences Research Council (BBSRC) project grant and NHS National Institute for Health Research (TS).