Genome-wide association study identifies eight loci associated with blood pressure

C Newton-Cheh; T Johnson; V Gateva; MD Tobin; M Bochud; L Coin; SS Najjar; JH Zhao; SC Heath; S Eyheramendy; K Papadakis; BF Voight; LJ Scott; F Zhang; M Farrall; T Tanaka; C Wallace; JC Chambers; KT Khaw; P Nilsson; P Van Der Harst; S Polidoro; DE Grobbee; NC Onland-Moret; ML Bots; LV Wain; KS Elliott; A Teumer; J Luan; G Lucas; J Kuusisto; PR Burton; D Hadley; WL McArdle; M Brown; A Dominiczak; SJ Newhouse; NJ Samani; J Webster; E Zeggini; JS Beckmann; S Bergmann; N Lim; K Song; P Vollenweider; G Waeber; DM Waterworth; X Yuan; L Groop; M Orho-Melander; A Allione; A Di Gregorio; S Guarrera; S Panico; F Ricceri; V Romanazzi; C Sacerdote; P Vineis; I Barroso; MS Sandhu; RN Luben; GJ Crawford; P Jousilahti; M Perola; M Boehnke; LL Bonnycastle; FS Collins; AU Jackson; KL Mohlke; HM Stringham; TT Valle; CJ Willer; RN Bergman; MA Morken; A Döring; C Gieger; T Illig; T Meitinger; E Org; A Pfeufer; HE Wichmann; S Kathiresan; J Marrugat; CJ O'Donnell; SM Schwartz; DS Siscovick; I Subirana; NB Freimer; AL Hartikainen; MI McCarthy; PF O'Reilly; L Peltonen; A Pouta; PE De Jong; H Snieder; WH Van Gilst; R Clarke; A Goel; A Hamsten; D Altshuler

Journal article

Genome-wide association study identifies eight loci associated with blood pressure

C Newton-Cheh, T Johnson, V Gateva, MD Tobin, M Bochud, L Coin, SS Najjar, JH Zhao, SC Heath, S Eyheramendy, K Papadakis, BF Voight, LJ Scott, F Zhang, M Farrall, T Tanaka, C Wallace, JC Chambers, KT Khaw, P Nilsson Show all

Nature Genetics | NATURE PORTFOLIO | Published : 2009

DOI: 10.1038/ng.361

Abstract

Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide. To date, identification of common genetic variants influencing blood pressure has proven challenging. We tested 2.5 million genotyped and imputed SNPs for association with systolic and diastolic blood pressure in 34,433 subjects of European ancestry from the Global BPgen consortium and followed up findings with direct genotyping (N 71,225 European ancestry, N 12,889 Indian Asian ancestry) and in silico comparison (CHARGE consortium, N = 29,136). We identified association between systolic or diastolic blood pressure and common variants in eight regions near the CYP17A1 (P = 7 × 10 24), CYP1A2 (P = 1 × 10..

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