Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A

S Nejentsev; JMM Howson; NM Walker; J Szeszko; SF Field; HE Stevens; P Reynolds; M Hardy; E King; J Masters; J Hulme; LM Maier; D Smyth; R Bailey; JD Cooper; G Ribas; RD Campbell; DG Clayton; JA Todd; PR Burton; LR Cardon; N Craddock; P Deloukas; A Duncanson; DP Kwiatkowski; MI McCarthy; WH Ouwehand; NJ Samani; P Donnelly; JC Barrett; D Davison; D Easton; D Evans; HT Leung; JL Marchini; AP Morris; CCA Spencer; MD Tobin; AP Attwood; JP Boorman; B Cant; U Everson; JM Hussey; JD Jolley; AS Knight; K Koch; E Meech; S Nutland; CV Prowse; NC Taylor; GR Walters; NA Watkins; T Winzer; RW Jones; WL McArdle; SM Ring; DP Strachan; M Pembrey; G Breen; D St Clair; S Caesar; K Gordon-Smith; L Jones; C Fraser; EK Green; D Grozeva; ML Hamshere; PA Holmans; IR Jones; G Kirov; V Moskvina; I Nikolov; MC O'Donovan; MJ Owen; DA Collier; A Elkin; A Farmer; R Williamson; P McGuffin; AH Young; IN Ferrier; SG Ball; AJ Balmforth; JH Barrett; DT Bishop; MM Iles; A Maqbool; N Yuldasheva; AS Hall; PS Braund; RJ Dixon; M Mangino; S Stevens; JR Thompson; F Bredin; M Tremelling; M Parkes; H Drummond; CW Lees; ER Nimmo

Journal article

Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A

S Nejentsev, JMM Howson, NM Walker, J Szeszko, SF Field, HE Stevens, P Reynolds, M Hardy, E King, J Masters, J Hulme, LM Maier, D Smyth, R Bailey, JD Cooper, G Ribas, RD Campbell, DG Clayton, JA Todd, PR Burton Show all

Nature | Published : 2007

DOI: 10.1038/nature06406

Abstract

The major histocompatibility complex (MHC) on chromosome 6 is associated with susceptibility to more common diseases than any other region of the human genome, including almost all disorders classified as autoimmune. In type 1 diabetes the major genetic susceptibility determinants have been mapped to the MHC class II genes HLA-DQB1 and HLA-DRB1 (refs 1-3), but these genes cannot completely explain the association between type 1 diabetes and the MHC region. Owing to the region's extreme gene density, the multiplicity of disease-associated alleles, strong associations between alleles, limited genotyping capability, and inadequate statistical approaches and sample sizes, which, and how many, lo..

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