Journal article

Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A.

Sergey Nejentsev, Joanna MM Howson, Neil M Walker, Jeffrey Szeszko, Sarah F Field, Helen E Stevens, Pamela Reynolds, Matthew Hardy, Erna King, Jennifer Masters, John Hulme, Lisa M Maier, Deborah Smyth, Rebecca Bailey, Jason D Cooper, Gloria Ribas, R Duncan Campbell, David G Clayton, John A Todd, undefined Wellcome Trust Case Control Consortium

Nature | Published : 2007

Abstract

The major histocompatibility complex (MHC) on chromosome 6 is associated with susceptibility to more common diseases than any other region of the human genome, including almost all disorders classified as autoimmune. In type 1 diabetes the major genetic susceptibility determinants have been mapped to the MHC class II genes HLA-DQB1 and HLA-DRB1 (refs 1-3), but these genes cannot completely explain the association between type 1 diabetes and the MHC region. Owing to the region's extreme gene density, the multiplicity of disease-associated alleles, strong associations between alleles, limited genotyping capability, and inadequate statistical approaches and sample sizes, which, and how many, lo..

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