Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A.
Sergey Nejentsev, Joanna MM Howson, Neil M Walker, Jeffrey Szeszko, Sarah F Field, Helen E Stevens, Pamela Reynolds, Matthew Hardy, Erna King, Jennifer Masters, John Hulme, Lisa M Maier, Deborah Smyth, Rebecca Bailey, Jason D Cooper, Gloria Ribas, R Duncan Campbell, David G Clayton, John A Todd, undefined Wellcome Trust Case Control Consortium
Nature | Published : 2007
The major histocompatibility complex (MHC) on chromosome 6 is associated with susceptibility to more common diseases than any other region of the human genome, including almost all disorders classified as autoimmune. In type 1 diabetes the major genetic susceptibility determinants have been mapped to the MHC class II genes HLA-DQB1 and HLA-DRB1 (refs 1-3), but these genes cannot completely explain the association between type 1 diabetes and the MHC region. Owing to the region's extreme gene density, the multiplicity of disease-associated alleles, strong associations between alleles, limited genotyping capability, and inadequate statistical approaches and sample sizes, which, and how many, lo..View full abstract
Awarded by Wellcome Trust
Awarded by Medical Research Council