AT1a receptors transfected into the caudal medulla of AT1a-/- mice inhibit the cardiovascular response to stress

Abstract

Brain angiotensin II (AngII) has been recognized as an important neuromodulator of cardiovascular responses induced by stress in several brain regions. The caudal ventrolateral medulla (CVLM) which is important for autonomic regulation is rich in AT1A receptors. In the present study, we examined whether the expression of AT1A receptors in the CVLM of AT1A−/− mice alters the baroreflex sensitivity and cardiovascular responses to stress. Bilateral microinjections of lentivirus with the catecholamine‐selective PRSx8 promoter driving expression of either green fluorescent protein (GFPv, n=9) (control) or AT1A receptors (AT1Av mice n=10) were made into the CVLM of AT1A−/− mice. Telemetry devices ..