Journal article

The Interplay of the Interleukin 1 System in Pregnancy and Labor

Yujing Jan Heng, Stella Liong, Michael Permezel, Gregory E Rice, Megan KW Di Quinzio, Harry M Georgiou

REPRODUCTIVE SCIENCES | SAGE PUBLICATIONS INC | Published : 2014

Abstract

This work assessed the temporal coexpression of interleukin 1 (IL-1) and its inhibitor, IL-1 receptor antagonist (IL-1ra), in the cervicovaginal fluid (CVF) beyond 24 weeks gestation including women in spontaneous term labor. Two cohorts of women were recruited at 24 to 35 weeks' gestation (n = 65) and in late pregnancy (>36 weeks' gestation; n = 88). The CVF was serially collected either every 4 weeks between 24 and 35 weeks' gestation (n = 123 samples) or weekly during late pregnancy (n = 240 samples). The IL-1 and IL-1ra were quantitated by enzyme-linked immunosorbent assay, and the effect of vaginal microflora and unprotected sexual intercourse were also investigated. The IL-1β and IL-1r..

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Grants

Awarded by National Health and Medical Research Council of Australia (NHMRC)


Awarded by NHMRC


Funding Acknowledgements

The author(s) disclosed receipt of the following financial support for the research, authorship and/or publication of this article: National Health and Medical Research Council of Australia (NHMRC) Development Grant (454451); Medical Research Foundation for Women and Babies; Y.J.H. was a recipient of the NHMRC Biomedical (Dora Lush) postgraduate research scholarship (454880).