Journal article

The Interplay of the Interleukin 1 System in Pregnancy and Labor

Yujing Jan Heng, Stella Liong, Michael Permezel, Gregory E Rice, Megan KW Di Quinzio, Harry M Georgiou



This work assessed the temporal coexpression of interleukin 1 (IL-1) and its inhibitor, IL-1 receptor antagonist (IL-1ra), in the cervicovaginal fluid (CVF) beyond 24 weeks gestation including women in spontaneous term labor. Two cohorts of women were recruited at 24 to 35 weeks' gestation (n = 65) and in late pregnancy (>36 weeks' gestation; n = 88). The CVF was serially collected either every 4 weeks between 24 and 35 weeks' gestation (n = 123 samples) or weekly during late pregnancy (n = 240 samples). The IL-1 and IL-1ra were quantitated by enzyme-linked immunosorbent assay, and the effect of vaginal microflora and unprotected sexual intercourse were also investigated. The IL-1β and IL-1r..

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Awarded by National Health and Medical Research Council of Australia (NHMRC)

Awarded by NHMRC

Funding Acknowledgements

The author(s) disclosed receipt of the following financial support for the research, authorship and/or publication of this article: National Health and Medical Research Council of Australia (NHMRC) Development Grant (454451); Medical Research Foundation for Women and Babies; Y.J.H. was a recipient of the NHMRC Biomedical (Dora Lush) postgraduate research scholarship (454880).