Quantifying mRNA coding growth genes in the maternal circulation to detect fetal growth restriction
Clare L Whitehead, Susan P Walker, Sonali Mendis, Martha Lappas, Stephen Tong
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | MOSBY-ELSEVIER | Published : 2013
OBJECTIVE: To examine whether mRNA circulating in maternal blood coding genes regulating fetal growth are differentially expressed in (1) severe preterm fetal growth restriction (FGR) and (2) at 28 weeks' gestation in pregnancies destined to develop FGR at term. STUDY DESIGN: mRNA coding growth genes were measured in 2 independent cohorts. The first was women diagnosed with severe preterm FGR (<34 weeks' gestation; n = 20) and gestation matched controls (n = 15), where the mRNA was measured in both maternal blood and placenta. The second cohort was a prospective longitudinal study (n = 52) of women whom had serial ultrasound assessments of fetal growth. mRNA coding growth genes in maternal b..View full abstract
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Awarded by NHMRC
M.L. and S.T. are supported by NHMRC Career Development Fellowships. C.W is supported by a Royal Australian and New Zealand College of Obstetricians and Gynaecologists Arthur Wilson Scholarship, a William Buckland Foundation Grant, and a Medical Research Foundation for Women and Babies grant. S.T. and S.W are supported by NHMRC Project grant number 1028521.