Journal article
Oxygen saturation and outcomes in preterm infants
BJ Stenson, WO Tarnow-Mordi, BA Darlow, J Simes, E Juszczak, L Askie, M Battin, U Bowler, R Broadbent, P Cairns, PG Davis, S Deshpande, M Donoghoe, L Doyle, BW Fleck, A Ghadge, W Hague, HL Halliday, M Hewson, A King Show all
New England Journal of Medicine | Published : 2013
Abstract
BACKGROUND: The clinically appropriate range for oxygen saturation in preterm infants is unknown. Previous studies have shown that infants had reduced rates of retinopathy of prematurity when lower targets of oxygen saturation were used. METHODS: In three international randomized, controlled trials, we evaluated the effects of targeting an oxygen saturation of 85 to 89%, as compared with a range of 91 to 95%, on disability-free survival at 2 years in infants born before 28 weeks' gestation. Halfway through the trials, the oximeter-calibration algorithm was revised. Recruitment was stopped early when an interim analysis showed an increased rate of death at 36 weeks in the group with a lower o..
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Awarded by Medical Research Council
Funding Acknowledgements
Funded by the Australian National Health and Medical Research Council and others; BOOST II Current Controlled Trials number, ISRCTN00842661, and Australian New Zealand Clinical Trials Registry numbers, ACTRN12605000055606 and ACTRN12605000253606.Supported by the National Health and Medical Research Council (project grant 352386, to the Australian trial), the Medical Research Council (grant number 73460, to the United Kingdom trial), and the New Zealand Health Research Council (project grant number 05-145, to the New Zealand trial); and by a grant from the United Kingdom's Biomedical Research Centres of the National Institute for Health Research (to Dr. Marlow). Masimo supplied the study oximeters under lease.