Homeobox gene transforming growth factor -induced factor-1 (TGIF-1) is a regulator of villous trophoblast differentiation and its expression is increased in human idiopathic fetal growth restriction
Niroshani A Pathirage, Melanie Cocquebert, Yoel Sadovsky, Mohamed Abumaree, Ursula Manuelpillai, Anthony Borg, Rosemary J Keogh, Shaun P Brennecke, Daniele Evain-Brion, Thierry Fournier, Bill Kalionis, Padma Murthi
MOLECULAR HUMAN REPRODUCTION | OXFORD UNIV PRESS | Published : 2013
Abnormal trophoblast function is associated with human fetal growth restriction (FGR). Targeted disruption of homeobox gene transforming growth β-induced factor (TGIF-1) results in placental dysfunction in the mouse. The role of human TGIF-1 in placental cell function is unknown. The aims of this study were to determine the expression of TGIF-1 in human idiopathic FGR-affected placentae compared with gestation-matched controls (GMC), to elucidate the functional role of TGIF-1 in trophoblasts and to identify its downstream targets. Real-time PCR and immunoblotting revealed that TGIF-1 mRNA and protein expression was significantly increased in FGR-affected placentae compared with GMC (n = 25 i..View full abstract
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Awarded by Australian National Health and Medical Research Council (NHMRC)
Funding support for this work was provided from the Australian National Health and Medical Research Council (NHMRC project grant #509140) award to P. M. U. M. is supported by the Victorian Government's Operational Infrastructure Program.