Nonequivalent Gene Expression and Copy Number Alterations in High-Grade Serous Ovarian Cancers with BRCA1 and BRCA2 Mutations

Joshy George; Kathryn Alsop; Dariush Etemadmoghadam; Heather Hondow; Thomas Mikeska; Alexander Dobrovic; Anna DeFazio; Gordon K Smyth; Douglas A Levine; Gillian Mitchell; David D Bowtell

Journal article

Nonequivalent Gene Expression and Copy Number Alterations in High-Grade Serous Ovarian Cancers with BRCA1 and BRCA2 Mutations

Joshy George, Kathryn Alsop, Dariush Etemadmoghadam, Heather Hondow, Thomas Mikeska, Alexander Dobrovic, Anna DeFazio, Gordon K Smyth, Douglas A Levine, Gillian Mitchell, David D Bowtell

CLINICAL CANCER RESEARCH | AMER ASSOC CANCER RESEARCH | Published : 2013

DOI: 10.1158/1078-0432.CCR-13-0066

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University of Melbourne Researchers

Gillian Mitchell Author The Sir Peter MacCallum Department of Oncology

Thomas Mikeska Author Clinical Pathology

David Bowtell Author The Sir Peter MacCallum Department of Oncology

Alexander Dobrovic Author Surgery - Austin Health

Gordon Smyth Author Mathematics and Statistics

Related Projects (2)

Molecular Epidemiology of Ovarian Cancer: The Australian Ovarian Cancer Study National Clinical Follow-Up Core

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AUSTRALIAN OVARIAN CANCER STUDY (AOCS): A MULTIDISCIPLINARY OVARIAN CANCER RESOURCE FOR THE GENOMICS ERA

Ovarian cancer is relatively uncommon and is histologically very diverse, making it difficult to analyse ovarian cancer at a molecular level..

Grants

Awarded by Ovarian Cancer Research Program of the U.S. Department of Defense

Awarded by National Breast Cancer Foundation

Awarded by U.S. Army Medical Research and Materiel Command

Awarded by National Health and Medical Research Council of Australia (NHMRC)

Funding Acknowledgements

This study was supported by the Ovarian Cancer Research Program of the U.S. Department of Defense (W81XWH-08-1-0684 and W81XWH-08-1-0685); Cancer Australia and the National Breast Cancer Foundation (ID509303, CG-08-07, ID509366); the Peter MacCallum Cancer Centre Foundation and the Cancer Council Victoria. AOCS was supported by the U.S. Army Medical Research and Materiel Command under DAMD17-01-1-0729, The Cancer Council Victoria, Queensland Cancer Fund, The Cancer Council New South Wales, The Cancer Council South Australia, The Cancer Foundation of Western Australia, The Cancer Council Tasmania and the National Health and Medical Research Council of Australia (NHMRC; ID400413, ID400281).