Journal article
Establishing lung gas volumes at birth: Interaction between positive end-expiratory pressures and tidal volumes in preterm rabbits
K Wheeler, M Wallace, M Kitchen, A Te Pas, A Fouras, M Islam, M Siew, R Lewis, C Morley, P Davis, S Hooper
Pediatric Research | NATURE PUBLISHING GROUP | Published : 2013
DOI: 10.1038/pr.2013.48
Abstract
Background:We investigated the effects of positive end-expiratory pressure (PEEP) and tidal volume (V T) on lung aeration, pulmonary mechanics, and the distribution of ventilation immediately after birth using a preterm rabbit model.Methods:Sixty preterm rabbits (27 d) received volume-targeted positive pressure ventilation from birth, with one of the 12 combinations of PEEP (0, 5, 8, or 10 cmH 2 O) and V T (4, 8, or 12 ml/kg). Outcomes included functional residual capacity (FRC), peak inflating pressure (PIP), dynamic compliance (Cd), and distribution of ventilation.Results:Increasing PEEP from 0 to 10 cmH 2 O increased FRC by 4 ml/kg, increased Cd by 0.2 ml/kg/cmH 2 O, and reduced PIP by 5 ..
View full abstractGrants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
This project was funded by Australian National Health and Medical Research Council (NHMRC) grant 384100 and supported by the Victorian Government's Operational Infrastructure Support Program. Travel funding was provided by the International Synchrotron Access Program managed by the Australian Synchrotron and funded by the Australian Government. K.W. is supported by a Monash University International Graduate Scholarship. P.D. and S.H. are in receipt of NHMRC research fellowships. M.K. is the recipient of an Australian Research Fellowship funded by the Australian Research Council.