Journal article
Resequencing and fine-mapping of the chromosome 12q13-14 locus associated with multiple sclerosis refines the number of implicated genes
A Cortes, J Field, EA Glazov, J Hadler, J Stankovich, MA Brown, A Baxter, AG Kermode, B Taylor, DR Booth, D Mason, GJ Stewart, H Butzkueven, J Charlesworth, J Wiley, J Lechner-Scott, L Tajouri, L Griffiths, M Slee, P Moscato Show all
Human Molecular Genetics | OXFORD UNIV PRESS | Published : 2013
DOI: 10.1093/hmg/ddt062
Abstract
Multiple sclerosis (MS) is a common chronic inflammatory disease of the central nervous system. Susceptibility to the disease is affected by both environmental and genetic factors. Genetic factors include haplotypes in the histocompatibility complex (MHC) and over 50 non-MHC loci reported by genome-wide association studies. Amongst these, we previously reported polymorphisms in chromosome 12q13-14 with a protective effect in individuals of European descent. This locus spans 288 kb and contains 17 genes, including several candidate genes which have potentially significant pathogenic and therapeutic implications. In this study, we aimed to fine-map this locus. We have implemented a two-phase s..
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Grants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
This work was supported by the National Health and Medical Research Council of Australia (NHMRC) (grant number 633275).