Journal article
Expression, Regulation and Putative Nutrient-Sensing Function of Taste GPCRs in the Heart
SR Foster, ER Porrello, B Purdue, HW Chan, A Voigt, S Frenzel, RD Hannan, KM Moritz, DG Simmons, P Molenaar, E Roura, U Boehm, W Meyerhof, WG Thomas
Plos One | Published : 2013
Open access
Abstract
G protein-coupled receptors (GPCRs) are critical for cardiovascular physiology. Cardiac cells express >100 nonchemosensory GPCRs, indicating that important physiological and potential therapeutic targets remain to be discovered. Moreover, there is a growing appreciation that members of the large, distinct taste and odorant GPCR families have specific functions in tissues beyond the oronasal cavity, including in the brain, gastrointestinal tract and respiratory system. To date, these chemosensory GPCRs have not been systematically studied in the heart. We performed RT-qPCR taste receptor screens in rodent and human heart tissues that revealed discrete subsets of type 2 taste receptors (TAS2/T..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This work was funded by the National Health and Medical Research Council of Australia (APP631443 to WGT). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.