Molecular Profiling of Human Mammary Gland Links Breast Cancer Risk to a p27( ) Cell Population with Progenitor Characteristics
Sibgat Choudhury, Vanessa Almendro, Vanessa F Merino, Zhenhua Wu, Reo Maruyama, Ying Su, Filipe C Martins, Mary Jo Fackler, Marina Bessarabova, Adam Kowalczyk, Thomas Conway, Bryan Beresford-Smith, Geoff Macintyre, Yu-Kang Cheng, Zoila Lopez-Bujanda, Antony Kaspi, Rong Hu, Judith Robens, Tatiana Nikolskaya, Vilde D Haakensen Show all
Cell Stem Cell | CELL PRESS | Published : 2013
Awarded by National Cancer Institute
Awarded by US Army Congressionally Directed Research
Awarded by NATIONAL CANCER INSTITUTE
We thank Lisa Cameron in the DFCI Confocal and Light Microscopy Core Facility, members of Dr. Massimo Loda's lab for technical assistance, members of our laboratories and Drs. Elgene Lim and David Livingston for their critical reading of this manuscript, Jonathan Yingling (Eli Lilly) for providing the LY2109761 TGF-beta receptor kinase inhibitor, Drs. Sally Knox, Jeffrey Lamont, and Dao Tuoc (Baylor University Medical Center-Baylor Sammons Cancer Center), Erin Bowlby (University of California San Francisco, San Francisco), and Drs. Eli Golomg and Pikarski (Hadassah Medical Centre) for their help with collecting tissue samples from patients with BRCA1/BRCA2 germline mutation. Samples from the Susan G. Komen for the Cure Tissue Bank at the IU Simon Cancer Center were used in this study. We thank contributors, including Indiana University who collected samples used in this study, as well as donors and their families, whose help and participation made this work possible. This work was supported by the Avon Foundation (to K. P. and S. S.), the National Cancer Institute P50 CA89383 and P01 CA080111 (to S.J.S., K. P., and A. L. R.), CA116235-04S1 (to K. P.), and CA087969 (to R. M. T.), the Susan G. Komen Foundation (to R. M., Y.S., I. H., J.E.G., and K. P.), the Terri Brodeur Foundation (to S. C.), US Army Congressionally Directed Research W81XWH-07-1-0294 (to K. P.), the Victorian Breast Cancer Research Consortium (to S.J.L., G. C., and E. W. T.), the St. Vincent's Hospital Research Endowment Fund and the Victorian Government's OIS Program (to E. W. T.), the Programme for Advanced Medical Education funded by Fundacao Calouste Gulbenkian (to F. M.), and the Cellex Foundation (to V.A.).