Enduring Effects of Early Life Stress on Firing Patterns of Hippocampal and Thalamocortical Neurons in Rats: Implications for Limbic Epilepsy
Idrish Ali, Patrick O'Brien, Gaurav Kumar, Thomas Zheng, Nigel C Jones, Didier Pinault, Chris French, Margaret J Morris, Michael R Salzberg, Terence J O'Brien
PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2013
Early life stress results in an enduring vulnerability to kindling-induced epileptogenesis in rats, but the underlying mechanisms are not well understood. Recent studies indicate the involvement of thalamocortical neuronal circuits in the progression of kindling epileptogenesis. Therefore, we sought to determine in vivo the effects of early life stress and amygdala kindling on the firing pattern of hippocampus as well as thalamic and cortical neurons. Eight week old male Wistar rats, previously exposed to maternal separation (MS) early life stress or early handling (EH), underwent amygdala kindling (or sham kindling). Once fully kindled, in vivo juxtacellular recordings in hippocampal, thala..View full abstract
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Awarded by NHMRC
This study was supported by the NHMRC (Project Grants #566843). The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.