Journal article

Dietary intake of B vitamins and methionine and breast cancer risk

Julie K Bassett, Laura Baglietto, Allison M Hodge, Gianluca Severi, John L Hopper, Dallas R English, Graham G Giles



PURPOSE: We investigated prospectively the relationship between dietary intakes of methionine and B vitamins associated with one-carbon metabolism and breast cancer risk, including modification by age, hormone receptor status and alcohol consumption. Interactions between different B vitamins and methionine were also examined. METHODS: During follow-up of 20,756 women from the Melbourne Collaborative Cohort Study for an average of 16 years, we ascertained 936 incident breast cancers. Dietary intakes were estimated using a 121-item food frequency questionnaire. Hazard ratios (HR) and 95 % confidence intervals were estimated using Cox regression. RESULTS: We found weak evidence for an inverse a..

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Awarded by NHMRC

Funding Acknowledgements

This study was made possible by the contribution of many people, including the original investigators and the diligent team who recruited the participants and who continue working on follow-up. We would also like to express our gratitude to the many thousands of Melbourne residents who continue to participate in the study. We would like to acknowledge the work of David Muller who checked all statistical analyses. Cohort recruitment was funded by VicHealth and The Cancer Council Victoria. This work was supported by infrastructure from the Cancer Council Victoria and Grants from the NHMRC (209057, 251533, 520316).