Journal article
Kinase Inhibitor Screening Identifies Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3 as Potential Modulators of TDP-43 Cytosolic Accumulation during Cell Stress
D Moujalled, JL James, SJ Parker, GE Lidgerwood, C Duncan, J Meyerowitz, T Nonaka, M Hasegawa, KM Kanninen, A Grubman, JR Liddell, PJ Crouch, AR White
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2013
Abstract
Abnormal processing of TAR DNA binding protein 43 (TDP-43) has been identified as a major factor in neuronal degeneration during amyotrophic lateral sclerosis (ALS) or frontotemporal lobar degeneration (FTLD). It is unclear how changes to TDP-43, including nuclear to cytosolic translocation and subsequent accumulation, are controlled in these diseases. TDP-43 is a member of the heterogeneous ribonucleoprotein (hnRNP) RNA binding protein family and is known to associate with cytosolic RNA stress granule proteins in ALS and FTLD. hnRNP trafficking and accumulation is controlled by the action of specific kinases including members of the mitogen-activated protein kinase (MAPK) pathway. However, ..
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Awarded by Japan Society for the Promotion of Science
Funding Acknowledgements
This research was funded by the Motor Neuron Disease Research Institute of Australia (Terry Quinn MND Research Grant), Australian Rotary Health, the Bethlehem Griffiths Research Foundation and CASS Foundation. ARW is a recipient of an Australian Research Council Future Fellowship. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.