Journal article

Mapping kainate activation of inner neurons in the rat retina

Lisa Nivison-Smith, Daniel Sun, Erica L Fletcher, Robert E Marc, Michael Kalloniatis

JOURNAL OF COMPARATIVE NEUROLOGY | WILEY-BLACKWELL | Published : 2013

Abstract

Kainate receptors mediate fast, excitatory synaptic transmission for a range of inner neurons in the mammalian retina. However, allocation of functional kainate receptors to known cell types and their sensitivity remains unresolved. Using the cation channel probe 1-amino-4-guanidobutane agmatine (AGB), we investigated kainate sensitivity of neurochemically identified cell populations within the structurally intact rat retina. Most inner retinal neuron populations responded to kainate in a concentration-dependent manner. OFF cone bipolar cells demonstrated the highest sensitivity of all inner neurons to kainate. Immunocytochemical localization of AGB and macromolecular markers confirmed that ..

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University of Melbourne Researchers