Journal article
The "sweet" side of a long pentraxin: How glycosylation affects PTX3 functions in innate immunity and inflammation
A Inforzato, PC Reading, E Barbati, B Bottazzi, C Garlanda, A Mantovani
Frontiers in Immunology | FRONTIERS MEDIA SA | Published : 2013
Abstract
Innate immunity represents the first line of defense against pathogens and plays key roles in activation and orientation of the adaptive immune response. The innate immune system comprises both a cellular and a humoral arm. Components of the humoral arm include soluble pattern recognition molecules (PRMs) that recognize pathogen-associated molecular patterns and initiate the immune response in coordination with the cellular arm, therefore acting as functional ancestors of antibodies. The long pentraxin PTX3 is a prototypic soluble PRM that is produced at sites of infection and inflammation by both somatic and immune cells. Gene targeting of this evolutionarily conserved protein has revealed ..
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Grants
Awarded by European Commission
Funding Acknowledgements
The financial supports of the European Research Council (ERC project HIIS), the European Commission (FP7-HEALTH-2011-ADITEC-280873 and FP7-HEALTH-F4-2008-TOLERAGE-202156), the Italian Association for Cancer Research, Cariplo Foundation (project 2009-2582), Regione Lombardia (project Metadistretti - SEPSIS), and Ministero della Salute (projects Ricerca Finalizzata 2008 and Ricerca Indipendente 2011), are gratefully acknowledged. Financial support from the National Health and Medical Research Council (NHMRC) of Australia (Project Grant #1032079) is also gratefully acknowledged. The Melbourne WHO Collaborating Centre for Reference and Research on Influenza is supported by the Australian Government Department of Health and Ageing.